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Welcome to the Cordy Lab at Wake Forest University!

regina joice cordy
Dr. Regina Joice Cordy, Assistant Professor of Biology, WFU

Our lab’s research focuses on the pathogenesis of the protozoan parasite Plasmodium, the etiological agent of malaria. The development of severe malaria is a multi-factorial process that is not well understood. In addition to host genetics and immunity, host factors such as the microbiome, metabolism and diet may explain some of the heterogeneity observed in malaria disease outcome, but much less is known about the role of these factors.

cordy teaching microscopy techniques
Wake Forest biology students work in the microscopy teaching lab viewing flagellated parasites in the Bio 321 Parasitology class.

Research

Our research involves a combination of laboratory, computational and field-based approaches to investigate this topic. Specific areas of research include the study of host-parasite interactions in tissue using histology and molecular biology approaches, and the analysis of plasma metabolome and gut microbiome data to identify key physiological perturbations that occur during malaria infection.

People

Primary Investigator

Regina Joice Cordy, Ph.D.

Teacher-Scholar Postdoctoral Fellow

Sukhpreet Kaur, Ph.D.

Lab Manager

Ryan Marie Kelly

Graduate Students

Heather Colvin

Dinah Nahid

Undergraduate Researchers

Danielle Farinella

Jordan Buzzett

Publications

Regina Joice Cordy’s publications are listed under: “Joice R”, “Joice Cordy R” and “Cordy RJ”

Joice Cordy R. Mining the Human Host Metabolome Toward an Improved Understanding of Malaria Transmission. Front Microbiol. 2020;11:164. doi: 10.3389/fmicb.2020.00164. eCollection 2020. Review.

Joyner CJ, Brito CFA, Saney CL, Joice Cordy R, Smith ML, Lapp SA, Cabrera-Mora M, Kyu S, Lackman N, Nural MV, DeBarry JD, Kissinger JC, Styczynski MP, Lee FE, Lamb TJ, Galinski MR. Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes. PLoS Pathog. 2019 Sep;15(9):e1007974.

Cordy RJ, Patrapuvich R, Lili LN, Cabrera-Mora M, Chien JT, Tharp GK, Khadka M, Meyer EV, Lapp SA, Joyner CJ, Garcia A, Banton S, Tran V, Luvira V, Rungin S, Saeseu T, Rachaphaew N, Pakala SB, DeBarry JD, Kissinger JC, Ortlund EA, Bosinger SE, Barnwell JW, Jones DP, Uppal K, Li S, Sattabongkot J, Moreno A, Galinski MR. Distinct amino acid and lipid perturbations characterize acute versus chronic malaria. JCI Insight. 2019 May 2;4(9). doi: 10.1172/jci.insight.125156. eCollection 2019 May 2.

Peterson MS, Joyner CJ, Cordy RJ, Salinas JL, Machiah D, Lapp SA, Meyer EVS, Gumber S, Galinski MR. Plasmodium vivax Parasite Load Is Associated With Histopathology in Saimiri boliviensis With Findings Comparable to P vivax Pathogenesis in Humans. Open Forum Infect Dis. 2019 Mar;6(3):ofz021. doi: 10.1093/ofid/ofz021. eCollection 2019 Mar.

Gardinassi LG, Arévalo-Herrera M, Herrera S, Cordy RJ, Tran V, Smith MR, Johnson MS, Chacko B, Liu KH, Darley-Usmar VM, Go YM, Jones DP, Galinski MR, Li S. Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling. Redox Biol. 2018 Jul;17:158-170. doi: 10.1016/j.redox.2018.04.011. Epub 2018 Apr 11.

Gardinassi LG, Cordy RJ, Lacerda MVG, Salinas JL, Monteiro WM, Melo GC, Siqueira AM, Val FF, Tran V, Jones DP, Galinski MR, Li S. Metabolome-wide association study of peripheral parasitemia in Plasmodium vivax malaria. Int J Med Microbiol. 2017 Dec;307(8):533-541. doi: 10.1016/j.ijmm.2017.09.002. Epub 2017 Sep 6.

Uppal K, Salinas JL, Monteiro WM, Val F, Cordy RJ, Liu K, Melo GC, Siqueira AM, Magalhaes B, Galinski MR, Lacerda MVG, Jones DP. Plasma metabolomics reveals membrane lipids, aspartate/asparagine and nucleotide metabolism pathway differences associated with chloroquine resistance in Plasmodium vivax malaria. PLoS One. 2017;12(8):e0182819. doi: 10.1371/journal.pone.0182819. eCollection 2017.

Coalson JE, Walldorf JA, Cohee LM, Ismail MD, Mathanga D, Cordy RJ, Marti M, Taylor TE, Seydel KB, Laufer MK, Wilson ML. High prevalence of Plasmodium falciparum gametocyte infections in school-age children using molecular detection: patterns and predictors of risk from a cross-sectional study in southern Malawi. Malar J. 2016 Nov 4;15(1):527. doi: 10.1186/s12936-016-1587-9.

Hsu T, Joice R, Vallarino J, Abu-Ali G, Hartmann EM, Shafquat A, DuLong C, Baranowski C, Gevers D, Green JL, Morgan XC, Spengler JD, Huttenhower C. Urban Transit System Microbial Communities Differ by Surface Type and Interaction with Humans and the Environment. mSystems. 2016 May-Jun;1(3). doi: 10.1128/mSystems.00018-16. eCollection 2016 May-Jun.

Chang HH, Meibalan E, Zelin J, Daniels R, Eziefula AC, Meyer EC, Tadesse F, Grignard L, Joice RC, Drakeley C, Wirth DF, Volkman SK, Buckee C, Bousema T, Marti M. Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda. Sci Rep. 2016 May 20;6:26330. doi: 10.1038/srep26330.

Joice R, Frantzreb C, Pradham A, Seydel KB, Kamiza S, Wirth DF, Duraisingh MT, Molyneux ME, Taylor TE, Marti M, Milner DA Jr. Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients. Mod Pathol. 2016 Apr;29(4):381-90. doi: 10.1038/modpathol.2016.27. Epub 2016 Feb 26.

Pelle KG, Oh K, Buchholz K, Narasimhan V, Joice R, Milner DA, Brancucci NM, Ma S, Voss TS, Ketman K, Seydel KB, Taylor TE, Barteneva NS, Huttenhower C, Marti M. Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection. Genome Med. 2015;7(1):19. doi: 10.1186/s13073-015-0133-7. eCollection 2015.

Joice R, Yasuda K, Shafquat A, Morgan XC, Huttenhower C. Determining microbial products and identifying molecular targets in the human microbiome. Cell Metab. 2014 Nov 4;20(5):731-741. doi: 10.1016/j.cmet.2014.10.003. Epub 2014 Nov 4. Review.

Joice R, Nilsson SK, Montgomery J, Dankwa S, Egan E, Morahan B, Seydel KB, Bertuccini L, Alano P, Williamson KC, Duraisingh MT, Taylor TE, Milner DA, Marti M. Plasmodium falciparum transmission stages accumulate in the human bone marrow. Sci Transl Med. 2014 Jul 9;6(244):244re5. doi: 10.1126/scitranslmed.3008882.

Shafquat A, Joice R, Simmons SL, Huttenhower C. Functional and phylogenetic assembly of microbial communities in the human microbiome. Trends Microbiol. 2014 May;22(5):261-6. doi: 10.1016/j.tim.2014.01.011. Epub 2014 Mar 5. Review.

Aguilar R, Magallon-Tejada A, Achtman AH, Moraleda C, Joice R, Cisteró P, Li Wai Suen CS, Nhabomba A, Macete E, Mueller I, Marti M, Alonso PL, Menéndez C, Schofield L, Mayor A. Molecular evidence for the localization of Plasmodium falciparum immature gametocytes in bone marrow. Blood. 2014 Feb 13;123(7):959-66. doi: 10.1182/blood-2013-08-520767. Epub 2013 Dec 13.

Joice R, Narasimhan V, Montgomery J, Sidhu AB, Oh K, Meyer E, Pierre-Louis W, Seydel K, Milner D, Williamson K, Wiegand R, Ndiaye D, Daily J, Wirth D, Taylor T, Huttenhower C, Marti M. Inferring developmental stage composition from gene expression in human malaria. PLoS Comput Biol. 2013;9(12):e1003392. doi: 10.1371/journal.pcbi.1003392. Epub 2013 Dec 12.

Joice R, Lipsitch M. Targeting imperfect vaccines against drug-resistance determinants: a strategy for countering the rise of drug resistance. PLoS One. 2013;8(7):e68940. doi: 10.1371/journal.pone.0068940. Print 2013. PubMed PMID: 23935910; PubMed Central PMCID: PMC3723804.